CYP17A1 CLIA Kit for Human(Homo sapiens) | EIAab.comCYP17A1 CLIA Kit for Human(Homo sapiens)

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CYP17A1 (Gene name),

Steroid 17-alpha-hydroxylase/17,20 lyase (Protein name ), CP17A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYP17A1(CYP17;S17AH);

Protein name:

Steroid 17-alpha-hydroxylase/17,20 lyase;

Alternative:

Cytochrome P450 17A1;CYPXVII;Steroid 17-alpha-monooxygenase(Cytochrome P450c17);Cytochrome P450-C17(Cytochrome P450c17);Steroid 17-alpha-monooxygenase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

Subcellular Location:

Membrane

Protein Attributes:

Sequence length:

508

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

508:

EAQAEGST

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P05093

STRING:

9606.ENSP00000358903

UniGene:

Hs.438016

SMR:

P05093

Pfam:

PF00067

MIM:

202110

KEGG:

hsa:1586

Uniprot:

P05093

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ELISA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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E2016r

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96T

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ELISA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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E2016h

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96T

ELISA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Cat.:

E2016c

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96T

ELISA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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E2016b

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96T

ELISA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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E2016m

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96T

ELISA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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E2016p

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96T

CLIA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Cat.:

U2016h

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96T

CLIA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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U2016c

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96T

CLIA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Cat.:

U2016r

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Cat.:

U2016p

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96T

CLIA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Cat.:

U2016b

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96T

CLIA Kit for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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U2016m

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96T

Polyclonal Antibody for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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P2016Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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P2016Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Steroid 17-alpha-hydroxylase/17,20 lyase

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P2016Rb-h

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Polyclonal Antibody for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Monoclonal Antibody for Human Steroid 17-alpha-hydroxylase/17,20 lyase

Protein for Human Steroid 17-alpha-hydroxylase/17,20 lyase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues."
Chung B.-C. , Picado-Leonard J. , Haniu M. , Bienkowski M. , Hall P.F. , Shively J.E. , Miller W.L.
Proc. Natl. Acad. Sci. U.S.A.84:407-411(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): similarity with the gene for P450c21."
Picado-Leonard J. , Miller W.L.
DNA6:439-448(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Characterization of complementary deoxyribonucleic acid for human adrenocortical 17 alpha-hydroxylase: a probe for analysis of 17 alpha-hydroxylase deficiency."
Bradshaw K.D. , Waterman M.R. , Couch R.T. , Simpson E.R. , Zuber M.X.
Mol. Endocrinol.1:348-354(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and phorbol ester-repressed transcription from the human P450c17 promoter in mouse cells."
Brentano S.T. , Picado-Leonard J. , Mellon S.H. , Moore C.C. , Miller W.L.
Mol. Endocrinol.4:1972-1979(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Structural characterization of normal and mutant human steroid 17 alpha-hydroxylase genes: molecular basis of one example of combined 17 alpha-hydroxylase/17,20 lyase deficiency."
Kagimoto M. , Winter J.S.D. , Kagimoto K. , Simpson E.R. , Waterman M.R.
Mol. Endocrinol.2:564-570(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
9.

"Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations."
Auchus R.J. , Miller W.L.
Mol. Endocrinol.13:1169-1182(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 48-501
10.

"Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001."
DeVore N.M. , Scott E.E.
Nature482:116-119(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 24-508 IN COMPLEXES WITH HEME; ABIRATERONE AND TOK-001;FUNCTION;CATALYTIC ACTIVITY;COFACTOR
11.

"Deletion of a phenylalanine in the N-terminal region of human cytochrome P-450(17 alpha) results in partial combined 17 alpha-hydroxylase/17,20-lyase deficiency."
Yanase T. , Kagimoto M. , Suzuki S. , Hashiba K. , Simpson E.R. , Waterman M.R.
J. Biol. Chem.264:18076-18082(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 PHE-53 DEL
12.

"Missense mutation serine106-->proline causes 17 alpha-hydroxylase deficiency."
Lin D. , Harikrishna J.A. , Moore C.C.D. , Jones K.L. , Miller W.L.
J. Biol. Chem.266:15992-15998(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 PRO-106
13.

"Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496)-->Cys, Gln(461)-->Stop) actually cause combined 17 alpha-hydroxylase/17,20-lyase deficiency."
Yanase T. , Waterman M.R. , Zachmann M. , Winter J.S.D. , Kagimoto M.
Biochim. Biophys. Acta1139:275-279(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 CYS-496
14.

"Compound heterozygous mutations (Arg 239-->Stop, Pro 342-->Thr) in the CYP17 (P45017 alpha) gene lead to ambiguous external genitalia in a male patient with partial combined 17 alpha-hydroxylase/17,20-lyase deficiency."
Ahlgren R. , Yanase T. , Simpson E.R. , Winter J.S.D. , Waterman M.R.
J. Clin. Endocrinol. Metab.74:667-672(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 THR-342
15.

"Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency."
Imai T. , Globerman H. , Gertner J.M. , Kagawa N. , Waterman M.R.
J. Biol. Chem.268:19681-19689(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AH5 SER-64 AND ILE-112 INS
16.

"Mutation of histidine 373 to leucine in cytochrome P450c17 causes 17 alpha-hydroxylase deficiency."
Monno S. , Ogawa H. , Date T. , Fujioka M. , Miller W.L. , Kobayashi M.
J. Biol. Chem.268:25811-25817(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 LEU-373
17.

"Deletion of amino acids Asp487-Ser488-Phe489 in human cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency."
Fardella C.E. , Zhang L.H. , Mahacholklertwattana P. , Lin D. , Miller W.L.
J. Clin. Endocrinol. Metab.77:489-493(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 487-ASP--PHE-489 DEL
18.

"Point mutation of Arg440 to His in cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency."
Fardella C.E. , Hum D.W. , Homoki J. , Miller W.L.
J. Clin. Endocrinol. Metab.79:160-164(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 HIS-440
19.

"Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients."
Laflamme N. , Leblanc J.-F. , Mailloux J. , Faure N. , Labrie F. , Simard J.
J. Clin. Endocrinol. Metab.81:264-268(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 TRP-96
20.

"The molecular basis of isolated 17,20 lyase deficiency."
Geller D.H. , Mendonca B.B. , Miller W.L.
Pediatr. Res.39:89A-89A(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AH5 HIS-347 AND GLN-358
21.

"17alpha-hydroxylase/17,20-lyase deficiency as a model to study enzymatic activity regulation: role of phosphorylation."
Biason-Lauber A. , Kempken B. , Werder E. , Forest M.G. , Einaudi S. , Ranke M.B. , Matsuo N. , Brunelli V. , Schoenle E.J. , Zachmann M.
J. Clin. Endocrinol. Metab.85:1226-1231(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AH5 LEU-35; PHE-53 DEL; TRP-96; ASP-177; GLU-330 DEL; CYS-417 AND HIS-496;PHOSPHORYLATION
22.

"Pitfalls in characterizing P450c17 mutations associated with isolated 17,20-lyase deficiency."
Gupta M.K. , Geller D.H. , Auchus R.J.
J. Clin. Endocrinol. Metab.86:4416-4423(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AH5 HIS-347; GLN-358 AND CYS-417
23.

"Combined 17alpha-hydroxylase/17,20-lyase deficiency caused by Phe93Cys mutation in the CYP17 gene."
Di Cerbo A. , Biason-Lauber A. , Savino M. , Piemontese M.R. , Di Giorgio A. , Perona M. , Savoia A.
J. Clin. Endocrinol. Metab.87:898-905(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AH5 CYS-93
24.

"Differential inhibition of 17alpha-hydroxylase and 17,20-lyase activities by three novel missense CYP17 mutations identified in patients with P450c17 deficiency."
Van Den Akker E.L.T. , Koper J.W. , Boehmer A.L.M. , Themmen A.P.N. , Verhoef-Post M. , Timmerman M.A. , Otten B.J. , Drop S.L.S. , De Jong F.H.
J. Clin. Endocrinol. Metab.87:5714-5721(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AH5 VAL-114; VAL-116; CYS-347 AND HIS-347
25.

"P450c17 deficiency in Brazilian patients: biochemical diagnosis through progesterone levels confirmed by CYP17 genotyping."
Martin R.M. , Lin C.J. , Costa E.M.F. , de Oliveira M.L. , Carrilho A. , Villar H. , Longui C.A. , Mendonca B.B.
J. Clin. Endocrinol. Metab.88:5739-5746(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AH5 TRP-96; ASP-329; CYS-362; ARG-406 AND LEU-428

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